Title |
Graphene biointerfaces for optical stimulation of cells
|
---|---|
Published in |
Science Advances, May 2018
|
DOI | 10.1126/sciadv.aat0351 |
Pubmed ID | |
Authors |
Alex Savchenko, Volodymyr Cherkas, Chao Liu, Gary B Braun, Alexander Kleschevnikov, Yury I Miller, Elena Molokanova |
Abstract |
Noninvasive stimulation of cells is crucial for the accurate examination and control of their function both at the cellular and the system levels. To address this need, we present a pioneering optical stimulation platform that does not require genetic modification of cells but instead capitalizes on unique optoelectronic properties of graphene, including its ability to efficiently convert light into electricity. We report the first studies of optical stimulation of cardiomyocytes via graphene-based biointerfaces (G-biointerfaces) in substrate-based and dispersible configurations. The efficiency of stimulation via G-biointerfaces is independent of light wavelength but can be tuned by changing the light intensity. We demonstrate that an all-optical evaluation of use-dependent drug effects in vitro can be enabled using substrate-based G-biointerfaces. Furthermore, using dispersible G-biointerfaces in vivo, we perform optical modulation of the heart activity in zebrafish embryos. Our discovery is expected to empower numerous fundamental and translational biomedical studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 8 | 17% |
Spain | 5 | 10% |
Argentina | 3 | 6% |
Mexico | 3 | 6% |
Germany | 2 | 4% |
United Kingdom | 2 | 4% |
Sweden | 1 | 2% |
France | 1 | 2% |
India | 1 | 2% |
Other | 0 | 0% |
Unknown | 22 | 46% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 42 | 88% |
Scientists | 3 | 6% |
Science communicators (journalists, bloggers, editors) | 2 | 4% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 129 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 25% |
Researcher | 21 | 16% |
Student > Doctoral Student | 11 | 9% |
Student > Master | 9 | 7% |
Student > Bachelor | 8 | 6% |
Other | 19 | 15% |
Unknown | 29 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 27 | 21% |
Physics and Astronomy | 18 | 14% |
Biochemistry, Genetics and Molecular Biology | 10 | 8% |
Materials Science | 10 | 8% |
Agricultural and Biological Sciences | 8 | 6% |
Other | 24 | 19% |
Unknown | 32 | 25% |