| Title |
Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa
|
|---|---|
| Published in |
Science Advances, July 2021
|
| DOI | 10.1126/sciadv.abg2286 |
| Pubmed ID | |
| Authors |
Guangpeng Ren, Xu Zhang, Ying Li, Kate Ridout, Martha L. Serrano-Serrano, Yongzhi Yang, Ai Liu, Gudasalamani Ravikanth, Muhammad Ali Nawaz, Abdul Samad Mumtaz, Nicolas Salamin, Luca Fumagalli |
| Abstract |
Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing of 110 accessions from worldwide origins. We show that C. sativa was first domesticated in early Neolithic times in East Asia and that all current hemp and drug cultivars diverged from an ancestral gene pool currently represented by feral plants and landraces in China. We identified candidate genes associated with traits differentiating hemp and drug cultivars, including branching pattern and cellulose/lignin biosynthesis. We also found evidence for loss of function of genes involved in the synthesis of the two major biochemically competing cannabinoids during selection for increased fiber production or psychoactive properties. Our results provide a unique global view of the domestication of C. sativa and offer valuable genomic resources for ongoing functional and molecular breeding research. |
Twitter Demographics
The data shown below were collected from the profiles of 425 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 66 | 16% |
| Canada | 20 | 5% |
| Japan | 18 | 4% |
| Spain | 16 | 4% |
| United Kingdom | 15 | 4% |
| France | 14 | 3% |
| Colombia | 7 | 2% |
| Netherlands | 6 | 1% |
| Germany | 5 | 1% |
| Other | 51 | 12% |
| Unknown | 207 | 49% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 346 | 81% |
| Scientists | 55 | 13% |
| Practitioners (doctors, other healthcare professionals) | 13 | 3% |
| Science communicators (journalists, bloggers, editors) | 11 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 244 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 244 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 12% |
| Student > Master | 25 | 10% |
| Student > Bachelor | 24 | 10% |
| Student > Ph. D. Student | 20 | 8% |
| Student > Doctoral Student | 14 | 6% |
| Other | 38 | 16% |
| Unknown | 94 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 63 | 26% |
| Biochemistry, Genetics and Molecular Biology | 36 | 15% |
| Unspecified | 12 | 5% |
| Medicine and Dentistry | 7 | 3% |
| Psychology | 5 | 2% |
| Other | 24 | 10% |
| Unknown | 97 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1047. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2023.
All research outputs
#14,025
of 24,524,436 outputs
Outputs from Science Advances
#203
of 11,357 outputs
Outputs of similar age
#585
of 432,466 outputs
Outputs of similar age from Science Advances
#8
of 452 outputs
Altmetric has tracked 24,524,436 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,357 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 120.6. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 452 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.